NeuShield Data Sentinel can protect any file type. The maximum size of a file that can be protected is customizable up to 512 GBs. By default it protects files up to 2 GBs in size.
The Free edition can protect any file type up to a maximum file size of 1 GB for workstations and 2 GBs for servers.
Note: it is not recommended to protect folders with active database files in it, such as the Microsoft SQL data folder or the Microsoft Exchange mailbox folder.